This paper explores the role of glycogen as a metabolic fuel source within neurons, specifically focusing on Glycogen-Dependent Glycolytic Plasticity (GDGP). Recent studies using sensors like HYlight in models such as Caenorhabditis elegans have identified that neurons can utilize glycogen to regulate glycolytic states during periods of high activity or transient hypoxia. This study highlights the essential role of PYGL-1, an ortholog of human glycogen phosphorylase, in sustaining this plasticity. Introduction
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Glycogen-Dependent Glycolytic Plasticity in Neuronal Function (GDGP) This paper explores the role of glycogen as
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GDGP becomes critical during conditions of transient hypoxia or mitochondrial dysfunction, acting as a backup fuel source to sustain synaptic vesicle recycling.