The official PC port is known for being technically unstable, but modern community fixes at PCGamingWiki can make it playable:
Prototype 2 requires approximately 10 GB of disk space and modern hardware (like an NVIDIA GeForce 8800 GT or better). The original Game Boy hardware cannot process the 3D graphics, physics, or AI of a modern open-world game. prototype-2-pc-game-highly-compressed-gameboy
If you are looking to play the actual PC version, these are the confirmed minimum specs from System Requirements Lab : Windows XP / Vista / 7 Processor: Intel Core 2 Duo 2.6 GHz or AMD Phenom X3 8750 Memory: 2 GB RAM The official PC port is known for being
There is no legitimate Game Boy or Game Boy Advance version of Prototype 2. prototype-2-pc-game-highly-compressed-gameboy