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The protein utilizes C2 domains to bridge synaptic vesicles to the plasma membrane (plasma membrane being the "target membrane").

Otoferlin engages the target membrane specifically through a large interface involving the N-terminal C2B and C-terminal C2F-C2G domains . Ca 2+raised to the 2 plus power tm,cc,jp

The study highlights that membrane binding involves a cooperative effort of multiple domains. The protein utilizes C2 domains to bridge synaptic

Sensing: The C2D domain is identified as critical, as disruptions in this area alter synaptic sound encoding. tm,cc,jp