: After ruling out heroin addiction and sexual abuse, House discovers a biological anomaly: Alex has never menstruated and has undersized ovaries.

The central case follows (played by Cameron Richardson ), a 15-year-old supermodel who collapses on a fashion runway after a violent, uncharacteristic outburst.

"Skin Deep" is frequently cited by fans and critics for its polarizing content:

: Alex presents with double vision, aggressive behavior, and cataplexy (sudden loss of muscle tone).

chromosomes), but because her body cannot process testosterone, she developed entirely female secondary sexual characteristics—leading to her "perfect" feminine appearance. The actual cause of her symptoms was located in her groin. Parallel Drama: House’s Pain and the Placebo

: Alex is diagnosed with Complete Androgen Insensitivity Syndrome (CAIS) . Genetically, she is male ( XYcap X cap Y