Atopy (EASY – 2027)

: Antigen-presenting cells perceive allergens (like pollen or dust mites) as danger signals, activating TH2 or ILC2 cells.

The core of atopy is a Type I hypersensitivity reaction driven by a Type 2 immune response.

: Systemic immune priming eventually leads to upper and lower airway inflammation. 3. Key Management Strategies

: Upon re-exposure, allergens cross-link IgE on the surface of mast cells, causing degranulation and the release of inflammatory mediators like histamine and leukotrienes. 2. The Atopic March

: Sensitization through inflamed skin can lead to early-onset food allergies.